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SEVENTH FRAMEWORK PROGRAMME
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International Research Staff Exchange Scheme

Full Title of the project

Study of protein dynamics in living cells after DNA damage.

Project summary

The project aims at strengthening research partnerships through staff exchanges, networking and dissemination activities between two European research organizations (Institute of Biophysics, Academy of Sciences of the Czech Republic,v.v.i.; Jagiellonian University, Poland) and one organization from Russian Federation (Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences).
This project addresses scientific issues related to “living cells study”. It is based on a 3 year joint programme of exchange staff members for periods ranging from 1 to 11 months, thus providing unique mobility possibilities to individual researchers and support to 3 research organizations to reinforce their long-term research co-operation.
The main task of this project is to analyze dynamics of chromatin-related proteins in living cells after induced DNA damage.
Cells have developed sophisticated mechanisms to overcome damage to DNA resulting in double-strand breaks (DSBs) induced by toxic agents of our environment. Improper repair of DSBs can lead to the development of cancer. Once a cancer has developed, radiation and chemotherapy are used to damage DNA in order to kill the tumor cells. Thus, the information of how cells respond to DNA damage is critical for understanding both the development of cancer and its therapy.
The synergy of Czech expertise and the experience of Polish and Russian partners in these areas is a perfect match that will allow further advancements of science. Integration of the newest equipments and technologies together: 3D Microscopy of living cells, FISH technique, immunohistochemistry, RT-PCR and Western blotting, ChIP-PCR, ChIP-on-chips, FRAP, FLIP, FRET techniques (Czech and Polish partners) and Scanning Flow Cytometry, Fluorescence Microscopy (Russian partners) should give the response to reach the aim of this project.
Each partner has extensive experience in international cooperation. This project gives the opportunity to expand and strengthen cooperation between European countries and promotes the integration of Russia into the European scientific community.
They plan to create and to continue the cooperation between partners, and in the near future, it will lead to a fruitful scientific collaboration, joint PhD programs for young scientists, workshops and trainings which will open to all students and young scientists.

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